Protein Details: Potassium voltage-gated channel subfamily KQT member 4

Protein ID

ICDB_Pro_1542

Protein Name

Potassium voltage-gated channel subfamily KQT member 4

Gene Name

Kcnq4

Organism

Rattus norvegicus (Rat)

Length

168 amino acids

AlphaFoldDB

AF-Q9JK96-F1-model_v4.pdb

Function

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea

Sequence

DRIRISISQKRTGPSKQHLAPPPIPTSPSSEQVGEASSPSKVQKSWSFNDRTRFRASLRLKPRCSAEEGPSEEVAEEKSYQCELTVDDVMPAVKTVIRSVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGPGDRKTREKGDKGPS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in both the inner (IHCs) and the outer hair cells (OHCs) of the cochlea. Reciprocal longitudinal gradients of expression is present in IHCs and OHCs. The strongest expression in IHCs is in the base of the cochlea and in the apex for OHCs. A basal to apical gradient of expression is also present in both type I and type II spiral ganglion cells.

DOI ID

10.1016/s0169-328x(00)00204-7